Investigation of red blood cell and platelet indices in adult dogs suffered from myxomatous mitral valve disease with and without pulmonary hypertension

Background Pulmonary hypertension (PH) is a common complication of cardiopulmonary disease. In dogs, PH commonly occurs secondary to myxomatous mitral valve disease (MMVD). Red blood cell and platelet indices including mean corpuscular volume (MCV), hemoglobin (MCH), concentration (MCHC), red distribution width (RDW), (MPV) (PDW), have previously been found be indicators for predicting prognosing in humans. Therefore, this study aimed investigate whether these are associated with MMVD and/or dogs. Methods Two hundred forty-six dogs were retrospectively recruited the classified into 4 groups: normal ( n = 49), =102), =17), MMVD+PH =78). A sub-analysis was performed without evidence according stage B1 =20), B2 =15), C =67). The data expressed as median (interquartile range). Results discussion No significant differences p < 0.05) MCV, RDW MPV among all groups (normal, MMVD, MMVD+PH). However, decreases MCH MCHC [22.40 (20.90-23.50) pg 35.25 (33.08-36.90) g/dL], [22.25 (20.85-23.98) 35.65 (33.30-37.33) g/dL] [21.20 (20.60-22.20) 33.80 (32.75-35.70) compared [24.29 (23.55-24.90) 38.20 (37.50-39.05) 0.001). Decreases PDW [15.10 (14.98-15.30) %] group [15.30 (15.10-15.50) 0.004). Sub-analysis showed decrease [21.00 (20.50-22.90) pg] (20.90-23.20) [36.55 (33.53-37.78) 0.004), [32.90 (32.00-35.00) 0.001) [35.30 (33.30-36.80) lower than those [38.20 g/dL]. (15.00-15.30) reduced 0.042) [15.35 (15.23-15.68) 0.002). MCH, negatively correlated left atrial ventricular size. Conclusion related precapillary postcapillary while severity but not presence PH.